Next Generation Single-Molecule Biophysics
CHIRLMIN JOO LAB
Using next-generation single-molecule fluorescence techniques, we investigate how small regulatory RNA mediates gene silencing (RNA interference) and anti-viral defense (CRISPR immunity and beyond). We develop single-molecule protein sequencing techniques for advanced proteomics analysis. We organized conferences in 2017, 2019, 2022 .
KEY PUBLICATIONS
Filius et al, "Full-length single-molecule protein fingerprinting" Nature Nanotechnology (2024)
Severins, Joo, van Noort, "Exploring molecular biology in sequence space: The road to next-generation single-molecule biophysics", Molecular Cell (2022)
Alfaro et al, "The emerging landscape of single-molecule protein sequencing technologies" Nature Methods (2021)
Kim, Loeff, Colombo, Jergic, Brouns, Joo "Selective loading and processing of prespacers for precise CRISPR adaptation" Nature (2020) (animation)
Cui, Klein, Hegge, Chandradoss, van der Oost, Depken, Joo "Argonaute bypasses cellular obstacles without hindrance during target search" Nature Communications (2019)
LAB NEWS
Oct 2024 Chirlmin gives a talk in Single-Molecule Sensors and NanoSystems International Conference
Oct 2024 Chirlmin gives a talk in HUPO 2024
Jul 2024 Carolien defends her PhD thesis
Jun 2024 Chirlmin gives a talk in EPFL
May 2024 Mike gives a talk in Norwegian Symposium on Proteomics
May 2024 Ivo defends his PhD thesis
Mar 2024 Carlos becomes Faculty of Impact fellow (NWO)
Feb 2024 Mike•Raman•Carlos's work published in Nature Nanotechnology (TU Delft, delta, genengnews, phys, newbeezer, myscience)
Feb 2024 Marianne joins our lab for her internship project
Feb 2024 Senne joins our lab for his bachelor project
Feb 2024 Carolien gives a talk in BPS Meeting
Jan 2024 We are awarded ERC Proof of Concept (TU Delft)
Jan 2024 Koushik gives a talk in Single-Molecule Biophysics Les Houches
See also news in 2011- 2023